A-54 The Relationship between Age and MMSE Performance Amongst Individuals with Heart Failure

Abstract Objective A previous meta-analysis assessing the impact of heart failure (HF) on cognition found HF group performed more poorly than healthy control (HC) global measures. The study observed a medium effect and moderate heterogeneity when using Mini-Mental Status Examination (MMSE) to measure HF’s cognition. current meta-regression explores whether mean age moderates performance MMSE comparing patients HC. Data Selection Two researchers independently searched eight databases, extracted data, calculated sizes as part larger study. Inclusion criteria were: (a) adults with diagnosis HF, (b) comparison HC, (c) adequate data calculate sizes. Articles were excluded if had other types organ failure, article was not available in English, or there risk sample overlap another included Twelve articles (HF n = 1166 HC 1948) included. unrestricted maximum likelihood computational model used for meta-regression. Synthesis Studies evidenced statistically significant size estimate (k 12, g 0.671, p < 0.001, I2 80.91%). (slope −0.023, 0.0022, Qmodel 5.26, df 1, 0.022). Conclusions Individuals Larger studies participants who younger compared older. Future research should continue delineate individuals HF.